Note 4:1 — INTRODUCTION.
Reading edition
Perhaps the most noteworthy plant omitted is Tobacco—Shakespeare must have been well acquainted with it, not only as every one in his day knew of it, but as a friend and companion of Ben Jonson, he must often have been in the company of smokers. Ben Jonson has frequent allusions to it, and almost all the sixteenth-century writers have something to say about it; but Shakespeare never names the herb, or alludes to it in any way whatever.