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The Chemical Constituents of Piper Methysticum

THE TOTAL RESINS.

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The total resins were brown in color, thick syrupy consistency and possessed the characteristic odor of the drug.

A molecular weight determination was made in the same manner as with the Barium acids, and the following data obtained.

Wt. of pipette before 18.7660

Wt. of pipette after 14.7160

Wt. of resin used 4.0500

Temperature before 3.52

Temperature after 3.71

Change in temperature .18

Volume 37 cc.

Constant for solvent 3280

Approximate molecular weight 2000

Combustions were made and the following data obtained.

Wt. of boat 3.4722 3.4720

Wt. of boat and resin 3.6355 3.6220

Wt. of resin .1633 .1500

Sulphuric acid tube 79.1051 79.3865

Tube plus water 79.2073 79.4770

Water .1022 .0905

Hydrogen equivalent .01136 .01006

KOH bulb 49.4316 50.8720

Bulb plus carbon dioxide 49.8350 51.2430

Carbon dioxide .4034 .3710

Carbon equivalent .12102 .1010

Percent Carbon 67.31% 67.3

Percent Hydrogen 6.9 % 6.7

Percent Oxygen 26.8 % 27.0

The total resins when placed on the end of the tongue produced a marked stinging sensation followed by a local anaesthesia. After the first stinging was produced the sensation was rather pleasant. The local anaesthesia persisted a long time, giving a sensation much the same as that produced by cocaine. The barium and iron acids also produced this local anaesthesia, but the initial stinging sensation was much more pronounced, which was probably due to the acid nature of the substance.

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