ON THE INHALATION OF CHLOROFORM, ETC. (continued 5)

Idiosyncrasy. The accidents from chloroform have frequently been attributed to idiosyncrasy in the patient. This, it may be observed, is not to give an explanation of them, but merely to state that they depend on something we do not understand; that something, however, being in the person to whom the accident happens. This view receives 232apparent support from the supposition that the chloroform has been inhaled in exactly the same manner in the fatal cases as in other instances; but this apparent support fails when it is pointed out that the supposed same manner is only an equally uncertain manner. The different effects that have been produced on the same patient at different times, and the great number of instances in which medical men have failed to make the patient insensible, show that most of the usual modes of exhibiting chloroform are extremely uncertain.

What most completely meets the question of idiosyncrasy, however, is the circumstance that in no fewer than eleven out of the fifty recorded cases of death from chloroform, the patient had previously inhaled this medicine without ill effects. In two other cases also, previous attempts had been made to make the patient insensible without success, on the day on which the accident occurred. In the above table of the fatal cases, those are indicated in which previous inhalations had taken place. In twenty-nine cases, I have concluded that the patient had not previously inhaled, for the medical man, having given an account of the state of his patient, and his reasons for administering the chloroform, would certainly have mentioned such a material fact as a previous inhalation if it had occurred. There are ten cases of which only a meagre account is given, and where a previous administration of chloroform may possibly have taken place without being mentioned; but if only eleven, out of the fifty patients, who died from chloroform, had inhaled it previously without ill effects, it is very clear that the fact of having inhaled it with a favourable result, gives no immunity from the possibility of accident. It would be impossible to say what proportion of the patients who have inhaled chloroform have inhaled it more than once, but it is not probable that they amount to more than 22 per cent., if so many.

233Alleged Impurity of the Chloroform. At one time accidents from chloroform were loosely attributed to impurity in the medicine, but this was only a guess, and is opposed to the facts. No case of accident has been traced to this cause, and in nearly all the cases of which the details are given, it is distinctly recorded, either that the chloroform was examined and found to be of good quality, or else that chloroform out of the same bottle had been used in other cases without ill effects. I have not thought it necessary to state this in quoting the individual cases.

Apparatus employed. Accidents were at one time, and in one quarter, attributed to the use of inhalers; and it is curious that this allegation was made at a time when no death from chloroform had yet occurred in any cases in which an inhaler was used, except one in America, and one in France, the accounts of which had not reached this country. It is possible that death might be occasioned by want of air from the use of a faulty inhaler, and a case will be mentioned in which this apparently occurred in the administration of sulphuric ether, but there is no recorded case of accident from chloroform in which death was occasioned in this way. In the cases of death previously recorded, a handkerchief, a piece of folded lint, hollow sponge, or some such simple contrivance, was used in thirty-four instances; in twelve cases, an inhaler of some kind or other was used; and in four cases, it is uncertain what were the means employed.

Alleged Exclusion of Air. The assertion has often been made that death might be caused by the vapour of chloroform excluding the air, and so causing asphyxia; but it has already been pointed out in this work that the physical properties of chloroform do not allow it to yield a quantity of vapour which would have that effect, and in much smaller quantity than this the vapour kills by a quicker way than 234asphyxia, I believe that the only elastic fluids which can cause death simply by excluding the atmospheric air are nitrogen and hydrogen.

Alleged Closure of the Glottis. At the trial which took place in Paris respecting the death of a porcelain dealer previously mentioned, M. Devergie gave evidence, and after saying that chloroform might cause death as a poison, if given in undue proportion, he added: “Also it closes the glottis, and offers an obstacle to respiration. Employed by M. Demarquay on himself, in very small doses, closure of the glottis was occasioned. It was possible that Le Sieur Breton had experienced that accident, and in that case the most able surgeon could not prevent death.”

I have not met with M. Demarquay’s account of his experiment, but I am happy to know that he did not die of the closure of the glottis. It may fairly be denied that a person could commit suicide in this manner if he wished, for he would either have to give up the attempt, or receive the vapour into his lungs, and experience its specific effects. When animals are placed in mixtures of vapour and air, they always breathe them, whatever the strength; and if the vapour amounts to eight or ten per cent., they die much more quickly than they would of mere closure of the glottis. Vapour of chloroform, when not largely diluted with air, is apt to cause cough and closure of the glottis, as soon as a little of it reaches the lungs; but this, so far from being a source of danger, is, as a general rule, a safeguard, by its preventing the patient from readily breathing air which is highly charged with vapour.

In commenting on the fatal case No. 12, which occurred in St. Thomas’s Hospital, I have suggested that the accident might have happened from liquid chloroform being dropped into the throat; but liquid chloroform is very different from the vapour; it causes a lasting irritation if applied to a 235mucous membrane; when used for toothache, it often blisters the gums. The irritation caused by the vapour, on the contrary, is only momentary, and its local action ceases directly it ceases to be inhaled; for what is left in the air-passages is immediately absorbed or expelled with the expired air. The glottis is not a vital organ of itself. Its closure only causes death by preventing the access of air to the lungs. The glottis does not remain permanently closed, I believe, from the contact of any elastic fluid, however irritating;^[135] but it does from the contact of a liquid, and persons who die by drowning, die with the glottis closed, for they do not fill their lungs with water. Therefore, if the vapour of chloroform did cause persistent closure of the glottis, and if a person were to hold it by force to the patient, the death it would occasion would be precisely like that in drowning. Death by asphyxia is a comparatively slow one. I find that when the access of air to the lungs is entirely cut off, death does not take place in less than three minutes and a half in guinea pigs, and four minutes in cats. In dogs, the process of asphyxia is still slower. Mr. Erichsen states, that on taking the average of nearly twenty experiments, the contractions of the ventricles continued for nine minutes and a quarter after the trachea had been closed, and that the pulsations of the femoral artery also were perceptible for an average period of seven minutes and a half. The process of drowning in the human subject is well known to occupy some minutes; and even if the pungency of the vapour of chloroform should entirely prevent the patient from breathing, and the medical man could overlook the fact that breathing was not going on, it cannot be supposed that he would use the force, and have the perseverance to 236cause his patient to die slowly by asphyxia. If any patient, therefore, has died from closure of the glottis, it must have been one in whom there was a great tendency to sudden death from any slight interruption to respiration. I do not know the particulars of the case respecting which M. Devergie was giving his evidence, but in those fatal cases previously related, in which the symptoms are sufficiently described, it is not probable that death took place in any instance from closure of the glottis. In the sudden death at St. George’s Hospital (page 209), it is possible that the slight pungency of the vapour might assist the fear under which the patient was labouring in impeding the breathing, and thus add to the distension of the right cavities of the heart, under which the patient apparently died.

In 1855, two years after M. Devergie had given the above opinion, Dr. Black, of St. Bartholomew’s Hospital, who has had great experience in the administration of chloroform, advanced a similar theory in the pamphlet previously alluded to. He did not, however, confine the effects of the supposed closure of the glottis to possibly causing a death here and there, as M. Devergie had done, but he attributed all the accidents which had happened to this cause, and not to the effects of chloroform in the system. He says that “the chloroform has not been even inhaled: its pungency was felt at the glottis, and its inspiration was immediately arrested. The patient would have removed the apparatus, but in this he was restrained. The struggle forthwith commenced, but up to the moment of his death, not a single inspiration took place.” These remarks were not applied to a single case, but generally to the accidents from chloroform. Dr. Black says: “Any concentration of the vapour of chloroform which can be breathed is safe; any condition of dilution which forces the patient to cough or hold his breath is dangerous, and if persevered in for even half a minute, 237may be fatal.... We have only to attend to the breathing; we may disregard all considerations affecting the relative proportion of the chloroform in the air which is breathed;... if the patient breathes easily he is in safety, whatever be the amount of chloroform which is passing into the lungs.”

In Experiment 28, previously related, where the respiration was kept up by a tube in the trachea, there could be no error in respect to the vapour of chloroform entering the lungs, when a bladder of air charged with ten per cent. of that vapour was substituted for the bladder of simple air; and the immediate paralysis of the heart was evident. An examination of the fatal cases, of which the particulars have been recorded, shows that death did not occur in the manner Dr. Black suggests. In the majority of the cases, the patients were rendered quite insensible by the chloroform, and the operation had either been commenced, or was on the point of commencing; when the fatal symptoms set in. In several other cases, the patients were partially under the influence of the vapour before the symptoms of danger commenced; and in the six cases where death occurred at the beginning of the inhalation, without loss of consciousness having been induced, the patients were not restrained in any way, and it was observed that they did breathe the chloroform; three of them were speaking up to the moment when the pulse stopped, and one took a full inspiration the moment before the fatal symptoms set in. It is only in eighteen of the fatal cases that there is any reason to suppose that the patient required to be held, and then only from mental excitement or muscular spasm, arising from the physiological effects of the absorbed chloroform. It is hardly possible that the struggles of a conscious patient from inability to breathe, would be mistaken for excitement or spasm caused by chloroform.

238In a case, No. 34, which occurred at St. Bartholomew’s Hospital whilst Dr. Black was present, and long before his pamphlet was written, the patient inhaled for five minutes, and sank off into a state of complete insensibility without alarming symptoms. The inhalation was discontinued, the patient moved into a proper position, and the operation just about to be commenced, when Dr. Black found the pulse to become extremely feeble and fluttering. Surely this patient breathed the chloroform, and died without any spasm of the glottis. In Case 48, so minutely related by Mr. Paget, the boy made one long inspiration, and became suddenly insensible. In a few seconds, the pulse suddenly failed, and then ceased to be perceptible, but the breathing continued for at least a minute afterwards. There was certainly no closure of the glottis in this instance.

Alleged Exhaustion from Struggling. In cases where the patients have struggled violently whilst getting under the influence of chloroform, the accidents have been attributed to a supposed exhaustion caused by the struggling.^[136] This opinion is, however, contrary to experience; for the patients who struggle violently are precisely those who bear chloroform the best, provided they do not breathe it in an insufficient state of dilution. They are generally cheerful and exhilarated by it, and are less liable to be depressed by its prolonged use, than those who come quietly under its influence. Although the patients who struggle bear the chloroform well, when it is carefully and judiciously administered, it is not improbable that the struggling has been now and then an indirect cause of accident. The muscular spasm and rigidity do not occur till about three-quarters as much chloroform has been absorbed as can be present in the system with safety; and, as the patients often hold their breath whilst struggling, and take deep inspirations suddenly 239and at long intervals, the greatest care is required that the vapour be administered in a very diluted state. In Cases 9, 44, and 47, the fatal symptoms came on whilst the patients were struggling; and in some other cases, the sudden failure of pulse occurred just after the struggling had ceased, rendering it probable that the patient inhaled too much of the vapour whilst struggling, or just as the spasmodic condition of the muscles was subsiding.

The circumstances just mentioned, are probably the cause why so many of the fatal cases occurred at that period of life when the body is most robust. Very nearly two-thirds (twenty-seven out of forty-one), of those cases in which the ages are recorded, occurred in persons of twenty years and under forty-five years of age, although the proportion of persons living at this period of life, in England and Wales, is only a little more than one-third of the entire population. The majority of the accidents from chloroform occurred also in the stronger sex, in which muscular rigidity and spasm are most frequent:—twenty-nine of the fatal cases happened to males, and only twenty-one to females. According to my experience, the females who inhale chloroform for surgical operations are nearly twice as numerous as the males; and although this may not be the proportion in every one’s practice, it is probable that females inhale this agent quite as frequently as the other sex, in every part of the world.

Sitting Posture. In some of the early cases of death from chloroform, the patients were inhaling it in the sitting posture, and it was surmised that this circumstance was the cause of death.^[137] An examination of the account of the fatal cases, however, does not bear out this supposition. In thirty-one instances the patients were lying, in nine instances sitting, and there are ten cases in which the position 240is not mentioned, and where from the nature of the operation it may have been either one or the other. In fully one-fourth of the cases of which I have kept notes of the administration of chloroform, the patients were seated in an easy chair; and as in forty fatal cases in which the position is known, only nine, or less than one-fourth, were seated, it does not appear that the position of the patient has had any share either in causing or preventing accidents.

Supposed Effect of the Surgeon’s Knife on the Pulse. Mr. Bickersteth alluded to a peculiar circumstance,^[138] which he thought would account for several of the deaths attributed to chloroform. He relates three instances in which the pulse suddenly ceased on the first incision by the surgeon, and commenced again in a few seconds, the breathing going on naturally all the time. All the three cases were amputation of the thigh, and occurred in the latter part of 1851. Mr. Bickersteth did not observe the circumstance again during the two following years, and I have never observed it, although I have very often examined the pulse at the moment when the operation began, especially after reading Mr. Bickersteth’s remarks. He supposes that the action of the heart was arrested by the shock of the incision, notwithstanding the patient was insensible. I should attribute the temporary stoppage of the pulse in these instances to the direct influence of the chloroform on the heart. The moment when the operation is commenced, is usually a few seconds after the inhalation has been discontinued, and when the effect of the chloroform is at its height. A portion of that which was left in the lungs having been absorbed, in addition to that which was previously in the system. And if the vapour inhaled just at last was not sufficiently diluted, it might paralyse the heart, but not so completely as to prevent the natural respiration from restoring 241its action, in those cases where respiration continues. I found in experiments on animals that, when the action of the heart has been suspended by the effect of chloroform, it can very often be restored by artificial respiration instantly applied; and it is extremely probable that an accident of this kind not unfrequently occurs during the administration of chloroform, and is remedied by the breathing, without being noticed. The pulse recovered itself, in the cases mentioned by Mr. Bickersteth, just as it does in animals after the heart has been nearly overpowered by chloroform. In the first case, the pulse remained imperceptible for a period of four or five seconds, the countenance at the same time becoming deadly pale. As it returned, it was at first very feeble, but in a few seconds, it regained its usual strength. In the second case, Dr. Simpson administered the chloroform, and after the operation remarked that the pulse had stopped suddenly just as the knife was piercing the thigh, and had recovered itself with a flutter almost immediately.

Mr. Bickersteth’s reason for attributing the stoppage of the pulse to the effect of the knife, rather than the chloroform, was that he had arrived at the conclusion from some experiments which he performed on animals, that the action of the heart cannot be arrested by chloroform, until the breathing has been first suspended. One of Mr. Bickersteth’s experiments (No. 5, on a half-grown cat) exactly resembles the experiment (No. 28 in this work) on a rabbit, which I had published upwards of a year before Mr. Bickersteth’s paper appeared, with the exception that in my experiment the artificial respiration was performed with air containing ten per cent. of vapour, and in Mr. Bickersteth’s the vapour was an unknown quantity. In both experiments, the heart of the animal was exposed. In that which I performed, three or four inflations of the lungs almost paralyzed the heart; and nine or ten inflations, which did 242not occupy half a minute, had the effect of paralyzing that organ irrecoverably. In Mr. Bickersteth’s experiment, the effect of the artificial respiration was as follows:—“After continuing it for seven minutes, the diaphragm, hitherto unaffected, began to move very irregularly and imperfectly; then its movements became slow and hardly perceptible; and, at the expiration of eleven minutes, they had ceased altogether. During all this time the heart’s action remained strong and regular, but now it got weaker and more rapid, and, in four minutes from the time the diaphragm had ceased acting, had become so feeble (still quite regular) that I feared every moment it would stop.” Mr. Bickersteth says he performed artificial respiration with air saturated with chloroform; but saturated or not, the vapour certainly did not exceed six per cent., and most likely was only between four and five, if the artificial resembled the natural respiration in quantity and frequency. The vapour which can be breathed for seven minutes without causing serious symptoms, and for eleven minutes without arresting the breathing, is of course incapable of stopping the action of the heart by its direct effect. It is scarcely so strong as that which one administers every day to patients with impunity. The vapour which is so diluted as to require to be added by small increments during one hundred and fifty inspirations, before the brain is even narcotized, cannot act directly on the heart, an organ which can bear a much larger amount of chloroform. Mr. Bickersteth fell into the error into which the Committee of the Society of Emulation of Paris afterwards fell, and argued from the rule to the exception. What he witnessed was the mode of death which would occur, if vapour of chloroform of the strength which can be safely inhaled, were deliberately continued till the death of the patient. But an accident from chloroform is an exception, and the mode of dying is as much an exception 243as the death itself, if the inquiry is extended to what this agent is capable of doing, instead of confining it to what one endeavours to effect with it in the human subject alone.

So many of the deaths during the inhalation of chloroform have occurred before the operation had commenced, or after it had proceeded some way, that Mr. Bickersteth’s explanation would not apply to a great number, even if it were correct; and when it is remembered that the operation is always commenced when the effect of the chloroform is expected to be at its height, the number of cases of cardiac syncope which have happened at the beginning of the operation is not greater than might be expected as the result of the effect of chloroform.

Sudden Death from other Causes. It has been more than once suggested that the deaths which have occurred, during the inhalation of chloroform, are of the same nature as the sudden deaths which have often occurred about the time of surgical operations, apparently without any adequate cause; and that in fact the accident and the chloroform may be a mere coincidence, and not connected as cause and effect. It has been already shown that the Commission of the Academy of Medicine of Paris made this suggestion in treating of the case of Madlle. Stock, and Dr. Simpson has more than once made a similar remark. On one occasion,^[139] he remarked, in speaking of chloroform:—“The first surgical cases in which it was used were operated upon in the Royal Infirmary here, on the 15th of November, 1847. Two days previously, an operation took place in the Infirmary, at which I could not be present, to test the power of chloroform; and so far fortunately so; for the man was operated upon for hernia, without any anæsthetic, and suddenly died after the first incision was made through the skin, and with the operation uncompleted.” I should say, so far unfortunately 244so, for whatever the cause of the man’s death, that cause could hardly have been present if the patient had been made insensible by chloroform; and so his life would in all probability have been saved. If he died either from fear or from pain, the chloroform would have prevented his death, by removing and preventing these causes; and if his death arose from simple exhaustion, it must be remembered that chloroform is a stimulant, during the first part of its administration, and, as a general rule, so long as it is actually in the system. Even Mr. Bickersteth, who thinks that the knife of the surgeon may have a direct influence on the heart when the patient is quite insensible, expresses his conviction that such an occurrence is far less likely to happen under the influence of chloroform than in the waking state.

I have omitted from the list of deaths by chloroform two cases which are usually attributed to that agent, namely, the case of Mr. Robinson’s patient, and the one at St. George’s Hospital, and have attributed them to fear; and I also rejected the case of the infant on which Dr. Aschendorf operated, for the reasons I stated; and it is quite possible that amongst the fifty cases I have retained, there may be one or two in which the death was not caused by chloroform, especially as the details of some of the cases are very meagre; but when all the circumstances of the cases are examined, and especially when the mode of death is compared to that which chloroform can be made to produce in animals, it cannot be supposed that the fatal event was a more coincidence in the whole fifty cases, or in any great number of them.

There are numerous instances recorded of sudden death during surgical operations, or just before intended ones, without any evident cause, except fear or pain, before the use of narcotic vapours was known; and some even since, in cases in which it was not thought worth while to use 245them. After the passage quoted above, Dr. Simpson continues:—“I know of another case in Edinburgh, where death instantaneously followed the use of an abscess-lancet without chloroform,—the practitioner, in fact, deeming the case too slight to require any anæsthetic.” Such events have, no doubt, often happened without being recorded; and it is extremely likely that the deaths of this kind which chloroform has prevented are quite as numerous as those it has occasioned by its own effects, but the medical profession will very properly not be satisfied with a result of this kind, if more can be done; and the endeavour of the practitioner of course is, whilst saving life as well as preventing pain by the use of this agent, to avoid as far as possible having any accident from its use.

Falling back of the Tongue. It has been alleged that the falling back of the tongue into the throat, under the deep influence of chloroform, might be the cause of death by suffocation; but this appears to be an error; for the muscles of the larynx and neighbouring parts preserve their action as long as the diaphragm, and contract consentaneously with it. When the breathing has ceased, the tongue is indeed liable to fall backwards, if the person in a state of suspended animation is lying on the back, and this circumstance requires to be attended to in performing artificial respiration.

STATE OF THE CHIEF ORGANS AFTER DEATH FROM CHLOROFORM.

A few years ago, I examined the viscera of the chest, and kept notes of the appearances, in thirty-seven animals killed by chloroform. They consisted of two dogs, twenty-two cats, one kitten, three rabbits, three guineapigs, two mice, two larks, and two chaffinches. Many of the animals were opened immediately after death, and the rest within a day or two. The lungs were not much congested in any instance. 246In seven of the animals, they were slightly congested; but in the remaining thirty, they were not congested. They were generally of a red colour, but in a few of the cats they were quite pale. I ascertained the specific gravity of the lungs of two of the cats, in which they presented the amount of vascularity I have most usually met with. The specific gravity was 0·605 in one instance, and 0·798 in the other. As many of the animals died in a way resembling asphyxia, the respiration ceasing before the circulation, it might at first be supposed that we should meet with the same congestion of the lungs; but by the time that the respiration is altogether suspended by the action of chloroform, that agent has begun already to influence the heart, which does not inject the blood into the lungs with the same force as when the respiration is mechanically prevented, whilst it is in full vigour. Besides, in the gaspings which so often take place when the heart is ceasing to act, the animal inhaling chloroform draws air freely into the lungs, whilst the asphyxiated animal is prevented from doing so.

As regards the condition of the heart, it was found in the two chaffinches that the auricles were filled with blood, whilst the ventricles were empty. The condition of the heart in the larks is not mentioned, but in all the thirty-three quadrupeds, the right auricle and ventricle were filled with blood. In ten of them, these cavities were much distended; and in some of these instances, the coronary vessels on the surface of the heart were distended also. The left cavities of the heart never contained more than a small quantity of blood, not exceeding a quarter of what they would hold.

The head was examined in only ten of the animals. The substance of the brain was found to be of the natural vascularity, and the sinuses were not very much distended, except in two instances.

247With respect to the state of the blood, it may be mentioned, that in every instance in which the chest was opened within an hour after death, the blood which flowed from the cut vessels coagulated immediately and firmly. In eighteen of the animals in which the blood was examined in the heart or large vessels, a day or two after death, it was found to be well coagulated in ten, loosely coagulated in seven instances, and quite fluid in one instance. I have not met with air in the bloodvessels, either in the above thirty-seven examinations, or in any of the numerous other animals that I have opened, after they have been killed by chloroform. The appearances I have met with in animals killed by this agent have usually been such as I have described in the above thirty-seven instances; but I long since ceased, as a general rule, to make careful notes of the appearances, as I did not meet with anything new.

In the fatal cases of inhalation of chloroform previously quoted, the lungs are related to have been congested more frequently, and to a greater extent, than I have met with in animals. But there is no standard of what should be called congestion; and probably many of the medical men who made the examinations were speaking by comparison with cases where persons die after illness, in a state of inanition. In the human subject, the right cavities of the heart, although generally full of blood, were found empty in several cases; but as I previously stated, it is almost certain that they were emptied after death, either by the artificial respiration which was employed, or in some other way.

The blood remained fluid in eighteen out of twenty-five cases of fatal accident from chloroform, in which an examination of the body was made and the condition of the blood recorded; whereas it was only quite fluid in one instance out of eighteen of the animals which were killed by chloroform, and not opened till a day or two afterwards. 248The fact of the blood coagulating more generally, in the animals on which I have experimented, than in the human subjects who died from chloroform, is probably due to their smaller size. I was formerly of opinion that the fact of the body of a small animal cooling more quickly than the human one was the probable explanation of this, but Dr. Richardson appears to have proved that the blood is kept in a liquid state by the presence of ammonia; and ammonia, we might expect, would escape more readily from the body of a small animal than from the human body. However this may be, it is pretty certain that the blood generally remains fluid in the human body after death from chloroform, only because it usually remains fluid in every kind of sudden death. When a patient dies slowly of illness, the body cools gradually before death takes place, and ammonia keeps exhaling in the breath, if Dr. Richardson is correct, whilst the formation of this alkali must be almost suspended. In many cases, we know that coagulation of the blood commences before the respiration and circulation have ceased. The blood which flows during surgical operations coagulates as quickly and firmly when the patient is under the influence of chloroform as at other times; and, as was mentioned above, the blood which flows from animals, just after they are killed by this agent, coagulates as well as usual; it follows, therefore, that if the coagulation of the blood were prevented by the chloroform, and not by the mere fact of sudden death, it would be by the presence of this agent in the blood after death, and not by any action which it exerted during the life of the patient.

FURTHER REMARKS ON THE PREVENTION OF ACCIDENTS FROM CHLOROFORM.

In consequence of the prevailing opinion that accidents from chloroform depended chiefly on the condition of the 249patient, the main endeavours to prevent a fatal result have taken the direction of a careful selection of the persons who were to inhale this agent. It may be doubted, however, whether this line of practice has had so much effect in limiting the number of accidents, as in curtailing the benefits to be derived from the discovery of preventing pain by inhalation. In nearly all the recorded cases of accident from chloroform, it is stated that the patients had been carefully examined, and such proofs of disease as were met with after death were chiefly those which had not been detected; and, as already has been stated, were probably not greater on an average than in the cases in which no accident happened.

I have not myself declined to give chloroform in any case in which a patient required to undergo a painful operation, whatever evidence of organic disease I have met with on careful examination; and although I have memoranda of upwards of four thousand cases in which I have administered this agent, I have not, as I believe, lost a patient from its use; the only person who died whilst under its influence having, in my opinion, succumbed from other causes, as I have already explained.

Many writers have stated that accidents from chloroform might always be prevented by a close attention to the symptoms, or to some particular symptom, as the pulse or the breathing. Several authors have attached the utmost importance to feeling the pulse, and have considered this measure of itself sufficient to avert danger; whilst others have asserted that attention to the pulse is of no use at all. Mr. Bickersteth, for instance, writes as follows, in the article from which I previously quoted. “But the pulse should not be taken as any guide during the administration of chloroform. It should be wholly disregarded except under certain circumstances, when syncope is to be feared from loss of blood during the performance of a capital operation. 250The pulse is only affected secondarily in consequence of the failure of the respiration.”

If the person administering chloroform was always quite sure that the vapour did not constitute more than five per cent. of the inspired air, it is quite true that the pulse might be wholly disregarded. I can never produce more certain and uniform results with chloroform than when I am giving it to small animals enclosed in glass jars, where of course the pulse cannot be felt. In surgical practice, however, where the amount of vapour in the inspired air is often very uncertain, watching the pulse may be of great service, irrespective of loss of blood; and although it will not always prevent accident, I am persuaded that it has saved many lives. In some of the accidents that have happened, the pulse has ceased suddenly, whilst it was being very carefully watched; but more usually it would show some signs of failure before entirely ceasing.

In giving chloroform freely to animals from a napkin or sponge, whilst the ear or the hand was applied over the heart, I have usually found that its pulsations became embarrassed and enfeebled before they ceased; and by withdrawing the chloroform when the heart’s action first became affected, the life of the animal could often be saved.

The importance of attending to the respiration of the patient has been previously noticed, and it is so obvious a symptom that it can hardly be disregarded, if anyone is watching the patient; it speaks, moreover, almost to one’s instincts, as well as to one’s medical knowledge. It is probable that no patient has been lost by disregard of the respiration, unless it be one or two whom no one was watching, or in which the head and shoulders were covered with a towel.

It has already been shown in this work, from experiments on animals, and from the physiological effects and physical 251properties of chloroform, that accidents from this agent would arise by its suddenly paralyzing the heart, if it were not sufficiently diluted with air; and a careful review of all the recorded cases of fatal accident shows that nearly every one of them has happened in this way, and not from any neglect in watching the symptoms induced, or mistaking their import.

The first rule, therefore, in giving chloroform, is to take care that the vapour is so far diluted that it cannot cause sudden death, without timely warning of the approaching danger; and the next rule is to watch the symptoms as they arise. A description of those symptoms, and what they indicate, has already been given.

I have previously stated that the most exact way of giving chloroform to a patient is to put so much of it into a bag or balloon as will make four per cent. of vapour when it is filled up with the bellows; but I have not often resorted to this plan, on account of its being somewhat troublesome. I have previously described (p. 81) the inhaler which I employ. By arranging the bibulous paper suitably, and by ascertaining, with the inhaler in the scales, how much chloroform a given quantity of air carries off at different temperatures, I am able to produce very uniform results in the administration of chloroform. But, as I previously stated, those who do not wish to have the trouble of studying a suitable inhaler, may give chloroform on a handkerchief without danger, and with results sufficiently certain, by diluting this agent with an equal measure of spirits of wine. As the spirit (nearly all of it) remains behind, it is desirable, in a protracted operation, to change the handkerchief or sponge, now and then, for a dry one.

TREATMENT OF SUSPENDED ANIMATION FROM CHLOROFORM.

It is probable that artificial respiration, very promptly 252applied, will restore all those patients who are capable of being restored from an overdose of chloroform. All the patients who are related to have been restored after this agent has occasioned a complete state of suspended animation, have been resuscitated by this means. It is only by artificial respiration that I have been able to recover animals from an overdose of chloroform, when I felt satisfied that they would not recover spontaneously. And under these circumstances I have not been able to restore them, even by this means, except when a tube had been introduced into the trachea, by an incision in the neck, before giving them what would have been the fatal dose.

M. Ricord succeeded in restoring two patients who were in a state of suspended animation by mouth to mouth inflation of the lungs. The first was a woman, aged twenty-six, who had been made rapidly insensible by a few inspirations of chloroform from a sponge. He had scarcely commenced the operation of removing some vegetations, when his assistant informed him that the pulse had ceased. The breathing also ceased about the same time.

In the second case, he completed the operation of circumcision, and the patient, a young man, not coming to himself, M. Ricord found that the breathing had ceased, and the pulse was becoming more and more extinct, and very soon ceased entirely, till restored by the artificial respiration.

After these cases, hopes were expressed that M. Ricord had discovered the means by which all patients might be restored from the over-action of chloroform; but these hopes have not been verified by events. In the first of the cases, the heart had probably not been so entirely paralyzed by the action of the vapour as sometimes happens, and in the second case, that organ was apparently not paralyzed by the chloroform at all. It was only after the breathing had ceased, that M. Ricord found the pulse was failing. This 253was a case, therefore, in which artificial respiration might reasonably be expected to restore the patient.

The following cases of resuscitation, from the over effects of chloroform, are related by Mr. Bickersteth in the paper previously quoted. They occurred in Edinburgh:

“Case 1. A boy was cut for stone by my friend Mr. Hakes, on the 29th of March, 1849. Chloroform was administered on a piece of sponge, and the full anæsthetic effect produced, before proceeding to tie him up in the ordinary position: the inhalation was continued, without any regard to his condition, until the operation had been completed—altogether about five minutes from the time he first became insensible. It was noticed that during the operation scarce a drop of blood escaped. When it was over, the child was found, to all appearance, dead; the muscles were flaccid; the surface of the body pale; the respiration had ceased; the pulse could not be felt; the heart sounds were not audible (but the room was by no means quiet); the eyes were half open; the jaw dropped; the pupils dilated; and the corneæ without their natural brilliancy. Several means were tried to resuscitate him, but without effect. At length artificial respiration was commenced; the air escaped with a cooing sound, as if from a dead body. After continuing it for a while, the breathing commenced, at first very slowly and feebly. Soon it improved. In two hours the child had quite recovered.”

“Case 2. In December 1851, a child, a few months old, was put under the influence of chloroform for the purpose of having a nævus removed from the right cheek. As soon as insensibility was produced, the operation was commenced—the handkerchief containing the chloroform remaining over the face, as some difficulty had been experienced in keeping up the anæsthetic effect. Suddenly the breathing ceased; the muscles became flaccid; the countenance pale and collapsed, 254and the lips of a purple colour. Artificial respiration was employed, and in less than a minute the breathing returned, and the child was restored.”

“Case 3. On the 6th of March, 1852, I had occasion to remove the finger of a robust, healthy-looking young man, in the Royal Infirmary. He was already under the influence of chloroform when I entered the room, and as there had been some difficulty in producing complete anæsthesia, and the last of the chloroform in the bottle was already on the handkerchief, it was thought advisable by my friend in charge of its administration to keep up the inhalation, in order to produce a coma sufficiently profound to last until the completion of the operation. It was therefore left over his face, and I commenced and removed the finger, slowly disarticulating it from the metacarpal bone. I distinctly recollect hearing the man breathing quickly and shortly; and I also remember, that when just about to look for the vessels, my attention was attracted to his condition, by not any longer hearing the respiration. The handkerchief was still on his face. I took it off, and found, to my consternation, that the breathing had ceased; the face was livid; the eyes suffused; the pupils dilated; the mouth half open. He was to all appearance dead; still the pulse could be distinguished as a small, hardly perceptible thread, beating slowly. Immediately artificial respiration was commenced. For a minute or two, his condition did not alter in any respect—then the lividity of the countenance increased, the pulse was no longer perceptible, and the sounds of the heart could not be satisfactorily heard. During the whole of this time, artificial respiration had been diligently employed, but still the air appeared to enter the chest very imperfectly. I despaired. I felt certain that the man was dead, and that no human aid could restore him; and if it had not been that those standing near me urged me to persevere, I 255believe I should then have deserted the case as hopeless. Just at this time it occurred to me to put my finger in the mouth and draw forward the tongue, in order to secure there being no impediment to the air entering the lungs. Retaining it in this position, we again began the artificial respiration, and found that then the chest was fully expanded by each inflation. After keeping it up for a minute or two, the gentleman, who had all along kept his hand on the pulse, exclaimed, to our delight, that he could again feel it—‘It was just like a slight flutter that reached the uppermost of his four fingers,’ all of them being placed over the course of the artery. It gradually became more distinct and firmer, and at the same time, the lividity of the face decidedly lessened. In another minute, the man made a slight inspiratory effort. I ceased directly the artificial respiration, and merely assisted the expiration by pressure upon the ribs. Another and another inspiration followed, and in a short time he breathed freely without assistance. The countenance became natural, and he appeared as if in a sound sleep. In half an hour, he spoke when roused; then he vomited, and complained of giddiness. In an hour afterwards, he had recovered sufficiently to walk home.

“Moments of intense anxiety appear much longer than they really are; but even allowing this, I am quite sure that, at the very least, five minutes elapsed from the time when the man ceased breathing before the first inspiratory effort took place, and that for not less than one minute the pulse was imperceptible, and the heart’s action almost, if not altogether, inaudible.”

“Case 4. A few weeks after the occurrence just described, I was assisting Mr. Syme in removing the breast of a lady. A gentleman, my superior in the hospital, was conducting the inhalation of chloroform. Anæsthesia was complete, and the breathing good, when the operation commenced. 256The chloroform was allowed to remain over the face during the whole time of its performance. Before it was over, I noticed the respiration become very quick and incomplete, and suggested, in consequence, the propriety of removing the handkerchief. My remark was neglected for eight or ten seconds, and then, just as it was taken away, the breathing ceased suddenly. The face became deadly pale; the eyes vacant; the lips livid. Instant dissolution appeared inevitable (the pulse was not felt). Artificial respiration was immediately commenced, but the air not entering the lungs freely, the tongue was pulled forwards, and retained so by the artery forceps. The chest then expanded freely with each inflation, the air escaping with a cooing sound. In rather less than a minute, the respiratory movements recommenced, but at first so slowly and imperfectly that it was necessary to assist expiration. When recovery was a little more established, the operation was completed. Before the putting in of the sutures, sensation had partially returned, and in a short time the lady had perfectly recovered.”

Mr. Bickersteth very properly adds: “There can be no doubt, that in the foregoing cases, a grievous error was committed by continuing the inhalation after anæsthesia was produced, and that it was in consequence of this, the accidents, so nearly fatal, occurred.”

As these accidents seem to have occurred from continuing the inhalation too long, they differ entirely from nearly all those which were actually fatal, and which, as we have seen, arose from the too great concentration of the vapour, and not from any want of care in watching the patient, so as to be able to leave off at the right moment, if it were possible. I have previously stated, that after breathing vapour of the proper strength for inhalation, animals may always be readily restored by artificial respiration after the 257breathing has ceased, provided the heart is still beating. In the cases related by Mr. Bickersteth, the heart had ceased to beat before the patients were restored; but in the third case, there is distinct evidence that the heart continued to beat for four minutes after the breathing had ceased. It was, therefore, certainly not paralyzed by the direct action of the chloroform. The patient was nearly in the condition of a drowned person, where we know that there is a good prospect of recovery by artificial respiration during the first few minutes after the breathing has ceased, even if the action of the heart be imperceptible. In the other three cases, also, it is probable that the breathing ceased before the action of the heart; and, at all events, this organ was not paralyzed so thoroughly as in the cases in which artificial respiration was promptly applied without effect.

Several other cases have been related in the medical journals in which patients have been restored by artificial respiration, after animation had been suspended, more or less completely, by chloroform; but the above remarks would, I believe, be applicable to all these cases.

Where patients have recovered under the use of other measures, without artificial respiration, it is probable that animation was not completely suspended, and that the recovery was spontaneous.

M. Delarue related a case of accident from chloroform to the Academy of Medicine, on August 20th, 1850, which was apparently of this nature. After administering the vapour, and when he was about to divide some sinuses in the thigh, he found that his patient (a woman) was in a state of collapse, and the breathing and pulse, “pour ainsi dire”, insensible. The face was injected, and there was a bloody froth at the mouth. The uvula was titillated, and there was immediate movement of the eyelids, which was 258soon followed by copious vomiting, and the patient recovered.^[140]

Such measures as dashing cold water on the patient, and applying ammonia to the nostrils, can hardly be expected to have any effect on a patient who is suffering from an overdose of chloroform; for they would have no effect whatever on one who has inhaled it in the usual manner, and is merely ready for a surgical operation, but in no danger. I have applied the strongest ammonia to the nostrils of animals that were narcotized by chloroform to the third or fourth degree, and it did not affect the breathing in the least. They recovered just as if nothing had been done. It is difficult to suppose a case in which the breathing should be arrested by the effects of chloroform whilst the skin remained sensible, yet it is only in such a case that the dashing of cold water on the patient could be of use. There is, however, no harm in the application of this and such like means, provided they do not usurp the time which ought to be occupied in artificial respiration; for this measure should be resorted to the moment the natural breathing has entirely ceased.

I have only seen two cases in which the patients seemed in imminent danger from the direct effects of chloroform. One of these occurred in 1853. It was the case of a child, aged six years, but small and ricketty, which had the greater part of the eyeball removed on account of melanotic disease. The usual inhaler was employed, and when the child seemed sufficiently insensible, it was withdrawn. The operation was commenced by introducing a large curved needle, armed with a thick ligature, through the globe of the eye, in order to draw it forward. As the needle was introduced, the child cried out a very little, and thinking the parents, who were in the adjoining room, would be 259alarmed, I poured some undiluted chloroform hastily on a rather large sponge, and placed it over the nostrils and mouth. The sponge became pressed by the surgeon’s hand closer on the nose than I intended, but it was removed after the child had taken a few inspirations. The operation was quickly concluded without any further sign of sensation than that mentioned above. At the end of the operation, the breathing was natural, but the face was pale, and the lips blue, and the limbs were also relaxed. I tried to feel the pulse at the wrist, but did not discover any. The chloroform had at this time been left off half a minute at least. The pallor and blueness continued, and in a little time the breathing became slow and embarrassed, and appeared about to cease altogether, the pulse being still absent. The windows were opened, and cold water dashed freely on the face. The child made gasping inspirations now and then, but they did not follow immediately, or seem connected with each application of the water. The gasps became more frequent, till the breathing was thoroughly reestablished, when the colour returned to the lips, and the pulse was again felt at the wrist. In a minute afterwards, the child was red in the face, and crying violently from pain, which was relieved by a little more chloroform. It appeared to be a minute or a minute and a half from the time when the sponge with chloroform was removed, till the breathing became of a gasping character. There is no doubt that in this case the heart was paralyzed, or nearly so, by the chloroform, and that its action was restored by the spontaneous gasping inspirations of the child. The accident could have been prevented by having the chloroform, which was put on the sponge, diluted with spirit.

The other case occurred in the latter part of 1852. I have no notes of it, as it took place at the beginning of an illness, which prevented me from writing for some time; 260but I recollect the chief particulars of it sufficiently well. The patient was a lady rather more than sixty years of age, rather tall and thin. She required to have a polypus removed from the nose. Mr. Fergusson, who was about to operate, was nearly an hour after the appointed time, and during this interval she was pacing up and down the room, apparently in a great fright. She was placed in an easy chair for the operation, and the pulse was small and feeble when she began to inhale. Nothing particular occurred during the inhalation, but just at the time when the patient was becoming insensible, the breathing ceased, and the pulse could not be felt. She appeared to have fainted, and was immediately placed on a bed which was in the room. I applied my ear to the chest, but could hear no sound whatever. Mr. Fergusson applied his mouth to that of the patient, and with a very strong expiration, inflated her lungs, so as to expand the chest very freely. I immediately heard the heart’s action recommence with very rapid and feeble strokes, as I had so often heard it recommence in animals. The patient soon began to make distant gasping inspirations, and the natural breathing and pulse were soon reestablished. Mr. Fergusson made only one or two inflations of the lungs after the first one, which of itself was the means of restoring the patient. It was about twenty minutes, however, before she became conscious; and during the greater part of this time there were spasmodic twitchings of the features and limbs on one side. In about an hour, she was pretty well; and on the following day the operation was performed without chloroform.

The most ready and effectual mode of performing artificial respiration is undoubtedly the postural method, introduced by Dr. Marshall Hall a little time before his death. It consists in placing the patient on the face and making pressure on the back; removing the pressure, and turning 261the patient on his side and a little beyond; then turning him back on the face and making pressure on the back again; these measures being repeated in about the time of natural respiration.

Whether the artificial breathing is successful or not must depend chiefly on the extent to which the heart has been paralyzed by the chloroform, as was previously observed. The fact of the breathing continuing after the action of the heart has ceased, in some of the fatal cases, shows that the heart may be so paralyzed as not to be readily restored by the breathing. It is probable that in all cases in which artificial respiration can restore the patient, its action would be very prompt; still it is desirable to persevere with this measure for a good while.

As already stated, there is every reason to conclude that the right cavities of the heart are distended with blood, in all cases of suspended animation by chloroform, and therefore it would be desirable to open one of the jugular veins if the artificial respiration does not immediately restore the patient. In opening animals, just after death from this agent, I have observed the contractions of the heart to return, to a certain extent, when the distension of its right cavities was diminished by the division of the vessels about the root of the neck. Opening the jugular veins has been resorted to in a few of the cases of accident from chloroform, but hitherto without success.

I have not succeeded in restoring an animal from an overdose of chloroform, by means of electricity, in any case where I felt satisfied that it would not recover spontaneously; and I have not heard of any patient being restored by its means. For keeping up respiration, mechanical means, such as the postural method, are better; as they cause air to enter the lungs without exhausting the remaining sensibility. If electricity be used, it should be directed 262towards restoring the action of the heart. It is probable that the electric current would not reach the heart without the help of the acupuncture needle; but it would be justifiable to use this in a desperate case, when other measures had failed. The needles should be coated with wax, or some other non-conductor of electricity, except near the points.

In the fatal cases Nos. 40 and 48, previously related, the action of the heart partially returned during the efforts that were made for the restoration of the patient, but did not become thoroughly reestablished. It is probable that the circulation through the coronary vessels of the heart was not restored in those cases, or else the blood which must have been freed from chloroform, in its passage through the lungs, would most likely have enabled the heart to recover completely. Dr. Cockle has expressed the opinion, which is very probable, that the blood enters the coronary arteries in a retrograde manner, during the diastole of the ventricles, when the aorta and other great arteries are contracting on their contents; if so, with a very feeble circulation, the elasticity of the aorta, perhaps, cannot sufficiently act to cause a backward current; and perhaps, also, the over-narcotism of the heart is itself an obstacle to the coronary circulation, on account of the congestion of the capillaries which always attends on narcotism.

The knowledge how seldom anything effectual can be done for a person who has inhaled a dose of chloroform from which he would not spontaneously recover, ought to impress the rule very strongly on every one, to use the greatest care in its administration.

263

EFFECT OF CHLOROFORM ON THE RESULT OF OPERATIONS.

Besides the great benefit conferred by chloroform in the prevention of pain, it probably confers still greater advantages by the extension which it gives to the practice of surgery. Many operations take place in children which could not be performed in the waking state; excisions of joints and tedious operations for the removal of necrosed bone are often performed on persons who would be altogether unable to go through them except in a state of anæsthesia; and the moving of stiff joints by force is an operation now frequently performed, although it would probably not have been thought of if narcotism by inhalation had not been discovered. The surgeon also obtains the ready assent of his patient to a number of other operations, where it would either not be obtained at all, or not at the most favourable time, if the patient had to suffer the pain of them.

The effect of chloroform cannot fail to be favourable, to a certain extent, in large operations. The patient is in a more tranquil and cheerful condition after the operation, than he would be in if he had suffered the pain of it. His pulse is usually of the natural frequency; and after an amputation, there is generally an entire absence of the starting of the stump, which was formerly so distressing. After all the minor operations in which chloroform is used, and which according to my experience comprise at least one-half of the cases, there is never a death; and the only inconvenience is a troublesome sickness of stomach in a very few instances. Moreover, when patients die after the more formidable operations, they succumb to causes which are well known, and were in operation before the practice of anæsthesia. I only know of a very few instances where there has been a reasonable doubt on the mind of the surgeon, 264whether the chloroform may not have had some share in preventing the recovery of the patient, after a severe operation. These were cases in which the sickness, which occasionally follows chloroform, continued for three or four days, indeed till the death of the patient. This is a point which it would be difficult to decide, for the latter part of the sickness might depend on the sinking state of the patient, and might have come on if chloroform had not been used. Moreover, as sickness is seldom very prolonged after chloroform in minor operations, except in persons who are not in a good state of health, it is most probable, that the patients who died after a great operation with continued sickness, would not have done well if no chloroform had been used.

Some attempts have been made to determine, by statistical inquiry, whether the result of operations has been more favourable since the introduction of anæsthesia. These attempts have been confined to the larger amputations, as they are the only operations which sufficiently resemble each other to admit of the application of statistical inquiry; and even in the case of these operations, the inquiries which had been made previously to the introduction of etherization differed widely in their results.

Dr. Simpson took great trouble, in the early part of 1848, to collect the account of the amputations of the thigh, leg, and arm, which had been performed under the influence of ether or chloroform in forty-nine of the hospitals in Great Britain; and for comparison, he collected from thirty British hospitals the results of the same amputations, for the two or three years preceding 1847. He found that the mortality in the period preceding the use of ether was 29 per cent. in these amputations, and the return of patients whose limbs had been amputated under the use of ether and chloroform gave a mortality of 23 per cent.; and he concluded 265that 6 per cent. of the lives of those who had undergone these amputations had been saved by the use of these agents. In his application for an account of cases, however, Dr. Simpson merely asked for the number of cases, and the number of deaths. Nothing was said as to the time when the amputations had been performed; and there is reason to believe that a number of cases still under treatment may have been included; some of which may have ended fatally after the returns were made. The cutting part of a large amputation is of very short duration. The loss of blood is not great; and patients hardly ever died during the performance of an amputation, but some time afterwards, of diseases which ether and chloroform have not been found capable of preventing. It was therefore not to be expected that these agents should save the lives of so many as 6 per cent. of those who underwent the larger amputations.

In the early part of 1849, I published an account of fifty-five amputations of the thigh, leg, and arm, in which I had administered ether or chloroform, and the mortality was 27 per cent.^[141]

Dr. James Arnott has lately been investigating this subject in a very persevering manner. During the last three or four years, all the cases of amputation performed in the London hospitals have been reported in the Medical Times and Gazette, together with their results; and Dr. James Arnott has stated that the average per centage of deaths, after the three kinds of amputation above mentioned, is 34·4 per cent. There is obviously no means of ascertaining what was the mortality after amputations in the hospitals of London before the use of ether and chloroform, but Dr. James Arnott brings forward four papers, which state the mortality for a short period, in four hospitals, a little time before the introduction of etherization. The number of 266cases in these papers is 174, and the number of deaths 41. Dr. James Arnott states the per centage of deaths to be 21·9,^[142] although it appears to me that it would be 23·5; and it may be remarked that the four papers from which these numbers are taken might probably not have been published if the numbers they contain had not been favourable. Dr. James Arnott, in a second table, gives the number of amputations and deaths from the several hospitals in London which are named. The cases are said to have occurred “during eighteen months from June 1855 to June 1856, inclusive;” here being obviously a mistake. The number of cases is 204, and the number of deaths 61; which would give a mortality of 29·9 per cent.; almost exactly the same as that which Dr. Simpson had obtained from thirty provincial hospitals before the use of ether. The numbers in Dr. Simpson’s table are 618 cases, and 183 deaths, or 29·6 per cent. Dr. James Arnott does not, however, mention the per centage of deaths in his second table, but gives another table, for a different period, in which the names of the hospital are not given. The numbers he gives in this table are 430 cases and 148 deaths, giving a mortality of 34·4 per cent. Dr. James Arnott therefore concludes that chloroform causes the death of upwards of 12 per cent. of those who inhale it for the purpose of undergoing amputation. It is evident that he can have had no experience of the effects of chloroform, or he would have perceived at once the error of his conclusions, for this agent is given for a much longer time than in amputations, in numerous operations of which the entire mortality is less than 12 per cent. In the removal of tumours of the female breast, for instance, more chloroform is generally administered than in an amputation, and the loss of blood is also much greater, yet the entire mortality after this operation 267is considerably less than that which Dr. J. Arnott supposes that chloroform adds to the ordinary mortality after amputations.

Dr. J. Arnott stated that the pyæmia, of which many of the patients died after amputation, had probably been rendered more prevalent and fatal by the use of chloroform; but Mr. Thomas Holmes, in one of his able replies to the remarks of Dr. Arnott, points out that pyæmia had been prevalent also in cases of compound fracture, and others in which the patients had no chloroform. He stated that this complaint had been more prevalent in St. George’s Hospital during the three years in which Dr. J. Arnott’s statistics of amputations had been collected, than in the previous five years, in which chloroform had been used.^[143]

A very valuable paper on the result of operations performed in the Newcastle Infirmary, before and since the use of ether and chloroform, was published last year by Dr. Fenwick.^[144] He says, respecting his tables, “in the first series are included the operations registered in the operation books of the Newcastle Infirmary from 1823 to 1843; but, as the record is imperfect, the actual period embraced is seventeen and a half years. In the second, are the operations registered since the first employment of ether; and as the use of anæsthetic agents has been general in all the more important operations since that time, these figures may be used to show any disadvantages likely to arise from the employment of chloroform.” Dr. Fenwick continues:—“Before the use of chloroform, there were registered 225 amputations of the thigh, leg, and arm, of which 54, or 24 per cent., died. Since the use of anæsthetic agents, 149 cases of similar operations have been recorded, of which 36 died, showing also a mortality of 24 per cent.

268“Before, however, we can draw any conclusion from such facts, we must carefully exclude all those circumstances which are already known to produce an effect upon the mortality of amputations. It is, for instance, well known that amputations performed on account of accidents are, on the whole, nearly twice as fatal as those required for long standing disease. Now, if we divide the foregoing numbers into these two classes, we shall find that before the introduction of chloroform there were 144 pathological amputations, with a mortality of 19 per cent.; while since its employment there have been only 61, of which 13 per cent. have died; and while of 81 traumatic amputations which took place in the former period 32 per cent. died, only 31 per cent. perished in the latter period. The equal mortality obtained from a general average of all amputations is thus seen to have arisen from the smaller comparative number of operations performed for diseases.”

After giving a table which shows the result of each kind of amputation in the two periods, he adds, “It is plain from the above table that since the employment of chloroform there has been a diminution of mortality; thus in amputations of the thigh for disease there has been 5 per cent. less death, while after accidents 17 per cent. have been restored to health, who formerly would have perished. In the pathological amputations of the leg there is a difference of 8 per cent. in favour of chloroform; and while one out of three died after the removal of the forearm for accidents in the former series of cases, no death had occurred out of eight in the latter. The only exceptions are to be found in the traumatic amputations of the leg, and in the pathological amputations of the arm. In the former there is an excess of deaths since the introduction of chloroform amounting to 5 per cent.; and in the latter, the cases, being 269only two in number, do not warrant us in drawing any deduction from them.”

Dr. Fenwick found that the mortality from lithotomy had been greater since the introduction of chloroform than before, but that the increase was confined to the cases occurring in adults; and he justly attributes this to the fact of the more favourable cases having been operated on by lithotrity. He says, “However paradoxical it may appear, I believe that as surgery improves the general average of mortality, both after amputations and lithotomy, will increase; in the former, from the operation being confined more and more to those suffering from accidents, and in the latter, from those with a healthy condition of the kidneys and bladder being selected for the action of the lithotrite, and the worst cases only submitting to the knife.”

Dr. Fenwick gives a table showing the causes of death in the fatal cases of lithotomy before the use of chloroform and afterwards, by which it is seen that, in the latter set of cases, a larger proportion of the patients had been afflicted with organic disease, in addition to the stone. He says:—“This table shows that the relative proportion of deaths arising from the operation in healthy persons has diminished since the use of chloroform, 58 per cent. having died in the former, and only 47 per cent. in the latter.”

Dr. Fenwick inquires into the result of a considerable number of operations in the Newcastle Infirmary, before and after the use of chloroform, in addition to those mentioned above; and gives the following summary towards the end of his paper.^[145] “We find that there has been a decrease in mortality since the introduction of chloroform in the following operations:—

270

Per cent.

Pathological amputations of the thigh 5

Traumatic amputations of the thigh 17

Pathological amputations of the leg 8

Amputation at the shoulder joint 7

Traumatic amputation of the arm 5

Pathological amputation of the forearm 33

Traumatic amputation of the forearm 16

Ligature of the brachial artery 20

Ligature of the arteries of the forearm 25

Amputation of the penis 11

Amputation of the testis 14

Excision of the elbow 30

Tumours of the axilla, etc. 8

Tumours of the bones, etc. 4

“There has been an increase of mortality in:—

Per cent.

Traumatic amputation of the leg 5

Pathological amputation of the arm 41

Lithotomy 10

Herniotomy 12

Amputation of the breast 1

Tumours of the head, etc. 5.”

Dr. Fenwick very properly remarks that other circumstances may have had an influence over the mortality of the various operations, as well as the fact of chloroform being used or not used: but his inquiry is very important, as it shows the result of operations in the same institution since the employment of ether and chloroform, and for a long period immediately preceding the use of those agents.

271

THE ADMINISTRATION OF CHLOROFORM IN THE DIFFERENT KINDS OF OPERATIONS.

General directions for the exhibition of chloroform have already been given, but it is desirable to say a few words regarding its employment in some of the individual operations of surgery.

Lithotomy. In this operation, it is advisable to have the patient placed on the operating table with his head supported by one or two pillows, and to administer the chloroform before the sound is introduced. This having been done, it is generally requisite to administer a little more vapour cautiously and gently, whilst the bandages are applied to the hands and feet, and the patient is drawn down towards the foot of the table. The bandaging should on no account be neglected in the adult patient. It would be an abuse of chloroform to carry its effects so far in every case that the slightest contraction of the muscles could not be excited by the use of the knife, merely to save the trouble of applying a bandage. In little children, the bandages are not usually employed; but in these cases, the person administering the chloroform should hold the head or shoulders of the little patient, just as the surgeon makes his first incision; for the two assistants who are holding the legs, and think they are doing a great deal of good, are really making a fulcrum to enable the child to push itself away from the surgeon, if it makes the least flinch, which it is almost sure to do, if the narcotism is not much deeper than there is any occasion for. In this operation the patient should be fully insensible when the surgeon makes his first incisions; and the chloroform must be repeated or not during the operation as occasion may require.

I have memoranda of fifty-seven cases in which I have administered chloroform in the adult, and thirty-four in 272children, down to the present time, the end of March 1858. It was my expectation that I should be able to give the result of these, and all the other important operations; but I have in a few cases either not ascertained whether the patient recovered or not, or have neglected to make a note of the circumstances at the time; and although the deficiencies might perhaps be made up by private correspondence, and by searching the books of three hospitals, I regret that I have not time at present for such an undertaking.

A large proportion of the above cases of lithotomy were performed by Mr. Fergusson, either in his private practice, or in King’s College Hospital, and the remaining operations were performed by a number of surgeons. On April 19th, 1855, Mr. Fergusson removed eight calculi, as large as pigeon eggs, from the bladder of a gentleman, aged sixty-nine, who had a favourable recovery.

On June 7th, in the same year, he removed fourteen calculi from the bladder of an elderly gentleman, who also recovered. In January 1857, he removed forty-two calculi from the bladder of a gentleman, aged sixty-six; twelve of them were nearly as large as chesnuts, and the rest about as big as hazel-nuts. This patient died, I think, within a fortnight. He had disease of the kidneys. A considerable number of the elderly men on whom lithotomy has been performed have had well marked symptoms of fatty degeneration of the heart; but the chloroform has acted favourably on all of them. In January 1853, Mr. Fergusson performed lithotomy in the country on a gentleman, aged sixty-four, removing a rather large calculus. The patient weighed eighteen stone; he had a pulse which was liable to intermit, some of his relations had died suddenly, and his usual medical attendant was very much alarmed about the chloroform; but its action was very satisfactory. The patient recovered his consciousness without sickness, or any 273unpleasant symptom; and he had a favourable recovery. On August 11th, 1855, I administered chloroform in King’s College Hospital to a man, aged seventy-five, whilst Mr. Fergusson performed lithotomy. The patient had suffered from apoplexy a year before; he was still paralyzed on one side, he had the arcus senilis well marked in both eyes, and the temporal arteries were very thick and rigid. He went through the operation well; the pulse being good all the time. He died on the fifth day, and the following appears in the Medical Times and Gazette respecting the appearances found after death. “At the autopsy, the cellular tissue of the pelvis was found infiltrated with pus. The kidneys were contracted, and occupied by many cysts; the ureters were inflamed and contained pus. The bladder was extensively sacculated, and its mucous membrane so much congested as to appear on the point of sloughing. There was no peritonitis. The heart was large and fatty, and its aortic valves diseased to a small extent. The brain was congested, and its bloodvessels extensively ossified.” On December 22nd, 1855, I administered chloroform in King’s College Hospital to a very fat man, aged sixty-one, with a soft weak pulse, and arcus senilis of the cornea. Mr. Fergusson performed lithotomy. He went well through the operation, and recovered promptly from the effects of the chloroform. He died on the seventh day, with purulent effusion into the left knee, and around the left shoulder. The heart was large and flabby, and the substance of the left ventricle was very friable. The right ventricle was dilated and thinned, and its walls were soft and friable, and encroached on externally by fat; at one place there seemed scarcely any muscular substance left.

I have memoranda of four cases of lithotomy in the female, in which the urethra was divided as well as dilated 274to extract the stone; and I recollect two other cases of the same kind of which I have no notes.

Lithotrity. I have memoranda of 155 operations of lithotrity in which I have administered chloroform. The number of cases of stone in which these operations took place was sixty, but some of the patients had operations performed, either without chloroform, or when it was administered by some one else. The earliest cases of lithotrity in which I administered chloroform were in St. George’s Hospital, and a great number of the patients to whom I have given it were the private patients of Mr. Fergusson, who is entirely satisfied of its utility in this operation. Speaking of this operation in his Practical Surgery (third ed., p. 800), he says: “I am of opinion that there is not any department of practical surgery in which anæsthesia has been of more service than in this.” I have administered chloroform in a few operations of lithotrity by Sir Benjamin Brodie; but I believe that he does not approve of it in this operation, as a general rule. The following are amongst the other surgeons whom I have frequently assisted by giving chloroform in this operation: Mr. Cæsar Hawkins, Mr. Cutler, Mr. Coulson, Mr. Charles Hawkins, and Mr. Henry Lee. Mr. Fergusson, in one of his operations, extracted some portions of gutta percha bougie round which a phosphatic calculus had formed. He was not informed of the presence of the bougie in the bladder, until it was extracted. On another occasion, a patient was brought from the country soon after a bougie of this description had broken off, and he extracted with the lithotrite the piece remaining in the bladder. It was between two and three inches in length.

It is generally desirable to make the patient quite insensible during the operation of lithotrity; and the patient sometimes groans during its performance, when he is in a 275condition that, so far as one can judge, he would show no sign of sensation under the use of the knife; but he, of course, has no recollection of the operation afterwards. The bladder is sometimes apt to expel the water which is injected, if the patient is not well under the influence of the chloroform; but when the vapour has been continued for a few minutes, and the narcotism is complete, the bladder will, I believe, always hold water as well as if the operation were performed in the waking state, and generally much better. There are some surgeons who occasionally raise the breech of the patient for a short time during this operation, so that the head becomes considerably lower than the body. Stout old men generally snore more loudly when in this position under the influence of chloroform; but I have not met with any ill effects, nor expected any, from the head being lowered for a short time. From ten to twenty minutes has been the most usual duration of the operations under chloroform at which I have been present.

I have administered chloroform six times in female children whilst Mr. Fergusson performed lithotrity. The patients were three in number. I think the calculus all came away after the first operation, and the second was only an examination of the bladder. I administered chloroform also, on one occasion, to a lady whilst Mr. Spencer Wells repeated the operation of lithotrity.

Section of the Urethra in the Perinæum. I have notes of 56 cases of this operation. A great proportion of them were performed by Mr. Fergusson, either in King’s College Hospital, or in private practice. Amongst the other surgeons whom I have assisted in this operation were the late Messrs. Guthrie, Bransby Cooper, and Avery. In a great number of the cases, it was impossible to get a catheter into the bladder until after the incision was made in the perinæum, 276and many of the operations were very tedious; several of them lasting above an hour. It is very desirable to apply the bandages in this operation, as in that of lithotomy, especially if the assistants are not numerous.

Other Operations for Stricture, etc. I have notes of four operations in which the stricture was divided internally by a urethratome; and of two operations in which the orifice of the urethra was enlarged; and of nine plastic operations to restore deficiencies of the walls of the urethra, congenital or otherwise. I have memoranda of 66 cases in which I have administered chloroform for sounding the bladder or the introduction of a catheter. In catheterism under chloroform the patient, of course, lies on his back, which is indeed the position in which he ought to be during this operation, when chloroform is not administered.

Amputation of the Thigh. This operation is often performed for disease of the knee, when the joint is in such a state of tenderness that the least motion causes great pain. In such cases, I have administered the chloroform to the patient in bed, before his removal to the operating table, and given a little more chloroform just before the operation was commenced. In King’s College Hospital, I have several times given the chloroform in the ward in such cases, before the patient was removed to the operating theatre; but in St. George’s Hospital, the passages and doors being wide, the patient has been carried on his bed into the theatre, where the chloroform was administered just before his being lifted on the table. In those cases in which the tourniquet is applied, in preference to pressure with the fingers, it should be adjusted as the patient is getting under the influence of the chloroform, and tightened just before the operation begins. It is desirable to keep the patient quite insensible till the limb is removed, and the femoral artery is tied; after which a little chloroform may be given whenever 277the patient shows by a slight flinch, or contraction of his features, that sensation is returning. A few patients have recovered their consciousness during the tying of the smaller arteries, and have entered into a conversation without feeling the pain, but this condition is quite the exception. I have notes of 49 cases of amputation of the thigh in which I have administered chloroform. Some of the patients, who were almost grown up to the adult age, did not know that the limb was removed till three or four days had elapsed.

Amputation of the Leg. I have notes of 31 cases in which I have administered chloroform during this amputation. The remarks made above with regard to amputation of the thigh are applicable to this operation.

Amputation of the Arm. I have only administered chloroform five times in this operation, and only in one case during the last seven years. This case was that of a boy, aged sixteen; Mr. Hancock was the operator, and the patient recovered. I have no note of the disease for which the operation was performed, but in two or three of the remaining cases, the arm was amputated on account of malignant disease of the forearm. In one of the operations, the patient was seated in an easy chair, but in the others, the patients were lying on a sofa, or operating table, with the head and shoulders a little raised.

Amputation of the arm has apparently been much less frequently performed of late years, owing to the increasing practice of performing excision of the elbow; and it appears to me that all the great amputations are much less frequently performed now than they were a few years ago. During a little more than nine months of 1847, I administered sulphuric ether in 32 amputations of the thigh, leg, and arm; and in the last ten years and four months, I have only administered chloroform in 85 of the same operations; 278in the last three years, indeed, in only 16 cases; so that the practice of amputation is still diminishing. This is due to the practice of anæsthesia, which enables the surgeon to explore and to remove diseased joints and portions of diseased bone by operations that would be too long and too painful to be endured in the waking state. This circumstance confirms the remark of Dr. Fenwick, previously quoted, that the mortality after amputations may be expected to become greater, as they will cease to be performed, except after accidents, or in very desperate cases.

Amputation of the Ankle. I have notes of 15 cases of amputation at the ankle. They were chiefly performed by Mr. Fergusson, and generally in the manner recommended by Mr. Syme, or nearly so; but latterly Mr. Fergusson and Mr. Partridge have, in three or four cases, adopted the modification of this operation introduced by Prof. Pirogoff, by which a portion of the os calcis is left.

Other Amputations. I have notes of nine cases of amputation of the forearm; four of these operations were performed in 1850, and only three since that year. I have memoranda of twelve cases in which I have given chloroform whilst Chopart’s or other partial operations of the foot were performed. Also of three cases in which Mr. Fergusson performed amputation at the knee, and three cases in which he performed amputation at the wrist in King’s College Hospital. I have notes also of 65 cases in which I have administered it during the amputation of one or more fingers or toes.

Operations for Necrosis. Anæsthesia is of the utmost service in these operations, which are often tedious, and would be of the most painful nature. The operations are of the most successful kind of any in surgery; they usually relieve the patient from a very painful affection, and leave no mutilation. I have administered chloroform in many 279cases of necrosis in which an operation could not have been undertaken without its assistance; and in a still larger number, in which the operation could not otherwise have been satisfactorily completed. I have memoranda of 197 cases of necrosis in which I have given chloroform. In 70 of these, the tibia was the bone affected; in 15 cases, the femur; in 24 cases, the humerus; in 14 cases, the radius, or ulna, or both of these bones; in 29 cases, the bones either of the carpus or tarsus, or metacarpus or metatarsus. I have notes of six cases of necrosis of the sternum; in five of these the operation was performed by Mr. Fergusson, and in one case by Mr. Solly. Great care was required in some of the cases to avoid going through into the chest with the bone nippers. There have been nine operations for necrosis of the os calcis. In one of these, Mr. Wm. Adams lately removed, along with the necrosed bone, a small bullet which had been in the bone for six years.

The other cases of necrosis comprise the upper and lower jaw, the parietal bone, the edge of the orbit, the scapula and clavicle, the sacrum, the ileum, and the phalanges of the fingers and toes.

Excision of the Head of the Femur. I have notes of five cases of this operation. They all occurred in children from eight to thirteen years of age. Three of the operations were performed by Mr. Fergusson, one by Mr. Bowman, and one by Mr. French; I also recollect assisting Mr. Henry Smith in a similar operation in a child in 1848, at a time when I did not keep any account of the operations in which I administered chloroform. In one of Mr. Fergusson’s operations, he removed some diseased portions of the acetabulum.

Excision of the Elbow. There is every reason to conclude that this excellent operation has been performed more frequently in consequence of the inhalation of narcotic vapours than it otherwise would have been. I have memoranda of 28019 cases of this operation in which I have exhibited chloroform; 18 of them were performed by Mr. Fergusson, and the remaining one was performed by Mr. Coulson, whilst Mr. Fergusson was present.

Excision of the Knee. I have notes of 17 cases in which I have given chloroform during the performance of this operation. Thirteen of the operations were performed by Mr. Fergusson, two by Mr. Bowman, one by Mr. Partridge, and one by Mr. Henry Smith.

This operation had been rarely performed till within the last seven years, and there is every reason to believe that it never would have been frequently performed, if the practice of producing anæsthesia had not been introduced. I shall speak of this operation again in treating of amylene.

Excision of Wrist. There have been two cases of this operation performed by Mr. Fergusson in King’s College Hospital.

The Removal of Tumours of the Upper Jaw. Mr. Syme, Mr. Lizars, and some other surgeons, expressed an opinion at one time that chloroform could not be safely used in this operation, as the blood would be liable to flow into the lungs. This is not the case, however, as the glottis retains its sensibility apparently unimpaired, if the influence of the chloroform is not too deep or long continued. It is only necessary to hold the head forward now and then, when the throat is very full of blood, in order to allow the patient the same opportunity of breathing that he would require if he were awake. A good deal of blood passes into the stomach in great operations about the mouth under the influence of chloroform; and if a few drops pass into the windpipe, they are coughed up again, as they would be in the waking state; there is, however, less appearance of suffocation in operations where the blood flows back into the throat, when the patient is insensible, than when he is 281awake. The glottis appears to retain some sensibility as long as a creature is capable of breathing, for I have placed the head of more than one cat under water after making them thoroughly insensible with chloroform, and the action of the respiratory muscles lasted more than two minutes, but no water entered the lungs.

I have always made the patient insensible in the usual way, with the inhaler, before the operation of removing tumours of the jaw, and have kept up the insensibility during the operation by means of a mixture of chloroform and spirit on a hollow sponge; or in cases in which I have not been provided with this mixture, I have put not more than fifteen or twenty minims of chloroform on the sponge at one time. Owing to the hands of the surgeon and his assistants being very much in the way, I have not always been able to keep the patient quite insensible throughout the operation. He has sometimes struggled or cried out, but there has been hardly any case in which the patient afterwards remembered any considerable part of the operation.

I have notes of twelve cases of removal of the upper jaw in which I have administered chloroform, in addition to four cases to which I alluded in the Medical Gazette, in the early part of 1849. In some of the cases, the malar bone was removed, as well as the superior maxillary. Eleven of these operations were performed by Mr. Fergusson, and the others were performed by Mr. Partridge, Mr. Henry Charles Johnson, Mr. Hewett, Mr. Henry Smith, and Mr. Haynes Walton.