Note 175 — Chapter VII · THE ROMANS.

The origin of the theriac, according to what Galen writes in his book De antidotis, is to be traced back to Mithridates, King of Pontus, who lived from the year 132 to the year 63 B.C. This king, patron of Art and Science, was, for his times, an eminent toxicologist. By making experiments on condemned criminals he sought to discover by what drugs the action of the various poisons, both mineral and vegetable, and those inoculated by the bites of poisonous animals might be counteracted. He afterward mixed the various antidotes together for the purpose of obtaining a remedy that might prove a preservative against the action of any poison whatever. This universal remedy, the receipt of which was carried to Rome by Pompey, the conqueror of that great king, was named mithridatium, after the name of him who had composed it. Andromachus modified the mithridate; he took away certain ingredients and added others, reducing the number of them from about eighty to sixty-five. The principal modification was that of introducing into the composition of this drug the flesh of the viper; wherefore, Galen is of the opinion that the theriac (so called from the Greek word therion, a noxious animal) was more efficacious than the mithridate against the bite of the viper. The theriac still exists in the French pharmacopeia, although considerably simplified. In every 4 grams it contains 5 centigrams of opium.