Note 13 — Front matter
Reading edition
His first wife was Dona Isabel, eldest daughter and heiress to the Catholic Kings. She died in 1498 leaving an infant son Dom Miguel, heir to Castile and Aragon as well as to Portugal. He died two years later when Dom Manoel married his first wife's sister, Dona Maria, by whom he had six sons and two daughters. She died in 1517, and next year he married her niece Dona Leonor, sister of Charles v. and daughter of Mad Juana. She had at first been betrothed to his eldest son Dom João. All these marriages were made in the hope of succeeding to the Spanish throne.