Note 22 — Chapter VII · GENERAL DIFFERENCES OF THE TWO LIVES WITH RESPECT TO VITAL POWER.

So, as long as the fluid is retained in the artery, which is easily done by means of ligatures, no pain is manifested; but when the irritating substance is carried by the vessels to the heart or to any other sensible part, we can easily conceive that the animal must experience pain, for the irritant always produces its effect, whether it be carried directly to the part or arrive there by means of the circulation.