Note 7 — GENERAL OBSERVATIONS.

With regard to many other medicines, the most useful maximum of dose is an interesting question. I am certain that the largest quantity which the stomach will receive, is not the most efficacious. The action between the medicine and the stomach must be mutual. If we take, for example, so innocent a medicine as the carbonate of iron, I expect more effect from the dose of a dram than half an ounce, which would incommode the powers of the stomach by its mass. The observation applies to all medicines which are of a very insoluble nature. I do not mean, in a general sense, that a small dose of a medicine has equal power with a large one, but that there is a point of increase, beyond which the efficacy becomes lessened.