Note 17 — Chapter IX · URIC ACID IN RELATION TO GOUT
Reading edition
Wells, in his “Chemical Pathology,” observes that the amount of uric acid that appears in the urine depends upon a variety of factors which may be summarised as follows:—
(1) The amount of purin bodies taken in the food upon which chiefly depends the amount of exogenous uric acid.
(2) The amount of destruction of tissue nucleo-proteins.
(3) The amount of purin bases formed in the muscle tissue.
(4) The amount of conversion of purin bases into the uric acid.
(5) The amount of destruction of uric acid, if any, occurring in the body.
(6) Possibly upon the capacity of the tissues to synthesize uric acid; and in case such power to synthesize uric acid exists upon the presence of the precursors of uric acid in the body.
(7) The retention of uric acid in the blood and tissues.
(8) The power of the kidney to excrete uric acid.
(9) The solubility of uric acid in urine—dependent upon the amount of neutral phosphates present, the temperature, reaction and concentration thereof.