Note 14 — Chapter VII · SOURCES OF URIC ACID

Quoting from the same article, Journal of Biological Chemistry, 1918, by Lewis, Dunn and Doisy, these authorities observe that—re glycocoll and alanine, Lusk concluded that “the chemical stimulation of protoplasm which is responsible for the phenomena of increased heat production (specific dynamic action) results from the action of their intermediary products, glycocollic and lactic acids, rather than from the amino-acids themselves. The phenomena of the stimulation of uric acid metabolism by amino-acids run parallel to those of the specific dynamic action of the amino-acids (except in the case of the dicarboxylic amino-acids), and it is possible that the same chemical factors are responsible for both.”