Note 83 — Front matter (continued 2)

A patient who had been an inveterate smoker of tobacco for years, on entering the hospital was placed in a hot water bath, and here he remained for half an hour. A frog and other aqueous animals placed in the same water after it had become cool, died instantly; showing that the patient had exuded by the pores of the skin sufficient nicotine to impregnate the water.