Editorial note — DE ORBE NOVO

[Note 2: The Infante Don Juan died in October, 1497, shortly after his early marriage with the Archduchess Margaret of Austria, and without issue. Isabella, Queen of Portugal, died after giving birth to a son, in whom the three crowns of Portugal, Castile, and Aragon would have been united had the prince not expired in 1500, while still a child. Doña Juana, second daughter of Ferdinand and Isabella and next heir, had married, in 1496, the Archduke Philip of Austria, Duke of Burgundy, and became the mother of Charles I. of Spain, commonly known by his imperial title of Charles V.]